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PT 8500: Systematic Review and Meta-Analysis in the Health Sciences: EBP

A research guide for Dr. Gordon Warren's class.

What is Evidence Based Practice?

Evidence based practice is the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients. That is, it integrates the best external evidence with individual clinical expertise and patients' choice.

Evidence based practice involves 5 steps:

    1. Ask a focused question to satisfy the health needs of a specific patient 

    • What is your clinical question? - use the PICO model to the right.
    • What type of clinical question is this?  Therapy?  Diagnosis?  Use the table below.
    • What is the best study design to answer this type of clinical question? Use the table below.

    2. Find the best evidence by searching the literature 

    • What is the highest level of literature to support the question?  See the pyramid to the lower right.
    • Where should you look for this material?  See the table below the pyramid.

    3.  Critically appraise the literature: testing for validity, clinical relevance, and applicability

    •   What are the results of the study?

    4. Apply the results in clinical practice

    5. Evaluate the outcomes in your patient

    Adapted from: the Centre for Evidence-Based Medicine and Sackett DL, Evidence based medicine: what it is and what it isn't. BMJ. 1996 Jan 13;312(7023):71-2.

        Clinical Filters

        What type of question are you asking and which would be best to support the evidence?

        Type of Question Type of Study/Methodology to Look at

        Double-Blind Randomized Controlled Trial; Systematic Review/Meta
        Analysis of RCT

        Diagnosis Controlled Trial; Systematic Review/Meta Analysis of
        Controlled Trial
        Harm Cohort studies
        Prognosis Cohort Studies; Case control, case studies
        Etiology Cohort studies
        Prevention Randomized Controlled Trial; Cohort studies
        Quality Improvement Randomized Controlled Trial
        Quality of Life Qualitative Study
        Cost Effectiveness Economic Evaluation
        Clinical Exam Prospective, blind comparison to gold standard

        Types of Study Designs

        A way of combining data from many different research studies. A meta-analysis is a statistical process that combines the findings from individual studies.  ExampleAnxiety outcomes after physical activity interventions: meta-analysis findings.  Conn V.  Nurs Res. 2010 May-Jun;59(3):224-31.

        Systematic Review
        A summary of the clinical literature. A systematic review is a critical assessment and evaluation of all research studies that address a particular clinical issue. The researchers use an organized method of locating, assembling, and evaluating a body of literature on a particular topic using a set of specific criteria. A systematic review typically includes a description of the findings of the collection of research studies. The systematic review may also include a quantitative pooling of data, called a meta-analysis.  ExampleComplementary and alternative medicine use among women with breast cancer: a systematic review.  Wanchai A, Armer JM, Stewart BR. Clin J Oncol Nurs. 2010 Aug;14(4):E45-55.

        Randomized Controlled Trial
        A controlled clinical trial that randomly (by chance) assigns participants to two or more groups. There are various methods to randomize study participants to their groups.  ExampleMeditation or exercise for preventing acute respiratory infection: a randomized controlled trial.  Barrett B, et al. Ann Fam Med. 2012 Jul-Aug;10(4):337-46.

        Cohort Study (Prospective Observational Study)
        A clinical research study in which people who presently have a certain condition or receive a particular treatment are followed over time and compared with another group of people who are not affected by the condition.  Example: Smokeless tobacco cessation in South Asian communities: a multi-centre prospective cohort study. Croucher R, et al. Addiction. 2012 Dec;107 Suppl 2:45-52.

        Case-control Study
        Case-control studies begin with the outcomes and do not follow people over time. Researchers choose people with a particular result (the cases) and interview the groups or check their records to ascertain what different experiences they had. They compare the odds of having an experience with the outcome to the odds of having an experience without the outcome.  ExampleNon-use of bicycle helmets and risk of fatal head injury: a proportional mortality, case-control study Persaud N, et al.  CMAJ. 2012 Nov 20;184(17):E921-3.

        Cross-sectional study
        The observation of a defined population at a single point in time or time interval. Exposure and outcome are determined simultaneously.  ExampleFasting might not be necessary before lipid screening: a nationally representative cross-sectional study.  Steiner MJ, et al.  Pediatrics. 2011 Sep;128(3):463-70.

        Case Reports and Series
        A report on a series of patients with an outcome of interest. No control group is involved.  ExampleStudents mentoring students in a service-learning clinical supervision experience: an educational case report.  Lattanzi JB, et al.  Phys Ther. 2011 Oct;91(10):1513-24.

        Ideas, Editorials, Opinions
        Put forth by experts in the field.  Example: Health and health care for the 21st century: for all the people. Koop CE.  Am J Public Health. 2006 Dec;96(12):2090-2.

        Animal Research Studies
        Studies conducted using animal subjects.  Example: Intranasal leptin reduces appetite and induces weight loss in rats with diet-induced obesity (DIO).  Schulz C, Paulus K, Jöhren O, Lehnert H.  Endocrinology. 2012 Jan;153(1):143-53.

        Test-tube Lab Research
        "Test tube" experiments conducted in a controlled laboratory setting.

        Adapted from Study Designs. In NICHSR Introduction to Health Services Research: a Self-Study Course. and Glossary of EBM Terms. 

        Forming an EBP question

        Breaking up your question into these 4 elements (which you can easily remember with the mnmeonic device PICO) will make your literature search process easier:

        Levels of Evidence

        The EVIDENCE PYRAMID is often used to illustrate the development of evidence. At the base of the pyramid is animal research and laboratory studies - this is where ideas are first developed. As you progress up the pyramid the amount of information available decreases in volume, but increases in relevance to the clinical setting.
  Adaptation of the Evidence Pyramid Diagram developed by the Medical Research Library of Brooklyn, SUNY Downstate Medical Center.

        Sources of research may be either pre-appraised (summaries), primary literature or more anecdotal.

        Type of Study Where to Find it
        Systematic Reviews or Meta-analysis Cochrane Library, MEDLINE, EMBASE
        Critically-Appraised Topics DynaMed, UpToDate
        Critically-Appraised Articles ACP Journal Club
        Randomized Controlled Trials Original articles (search MEDLINE, EMBASE)
        Cohort Studies Original articles (search MEDLINE, EMBASE)
        Case-Controlled Studies etc. Original articles (search MEDLINE, EMBASE)
        Background Info/Expert Opinion Books, editorials

        EBP Tutorials

        PICO Search Tools