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Ask: Ask an answerable clinical question based on the health needs of a specific patient (may use the PICO framework: Patient, Intervention, Comparison, Outcome).
Acquire: Find the best available evidence by searching the literature.
Appraise: Critically appraise the literature: check for validity, clinical relevance, and applicability.
Apply: Apply the evidence in your clinical practice.
Assess: Evaluate your performance (are you improving outcomes in your patient?)