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"Evidence-based practice (EBP) is an approach to health care wherein health professionals use the best evidence possible, i.e., the most appropriate information available, to make clinical decisions for individual patients. ... It involves complex and conscientious decision-making based not only on the available evidence but also on patient characteristics, situations, and preferences." 
Evidence-based practice involves 5 steps:
Formulate a searchable question to satisfy the health needs of a specific patient
Search the literature efficiently
Read and critically evaluate the retrieved information to help make a clinical decision
Carry out the decision
Evaluate the outcomes of the applied evidence in your practice or patient [1 & 2]
There is a range in quality of evidence available in the literature, with systematic reviews being the very highest quality:
Indexes 3,000 journals from the fields of nursing and 17 allied health fields. Also indexes health carebooks, selected conference proceedings, standards of practice, book chapters, and Evidence-Based Care Sheets. Here is an excellent guide from UAB to help you find evidence-based practice articles in CINAHL.
Click Advanced Search and see Evidence-Based Practice check box on bottom under Limit your results.
A service of the U.S. National Library of Medicine that indexes MEDLINE citations and other life science journals for biomedical articles.
See Clinical Queries link on left sidebar and Find Systematic Reviews section.
Can also use options under Limits tab to limit a normal PubMed search to certain Type of Article, such as Clinical Trial, Meta-Analysis, Practice Guidelines, Randomized Controlled Trial, Review, Guideline, etc.
Includes MeSH term searching. This is accessible by using the top drop-down menu to the left of the search box and selecting MeSH.
Unique source of reliable and up-to-date information on the effects of interventions in health care. Designed to provide information and evidence to support decisions taken in health care and to inform those receiving care.
Search box in top right.
Results broken out into 7 categories. Most valuable ones are Cochrane Reviews, Other Reviews, and Clinical Trials.
Sources used to create this guide
 McKibbon KA. Evidence-based practice. Bull Med Libr Assoc. 1998 Jul;86(3):396-401.
 Evidence-Based Practice in the Health Sciences: Evidence-Based Practice in Applied Health Tutorial
 EBM Pyramid and EBM Page Generator, copyright 2006 Trustees of Dartmouth College and Yale University. All Rights Reserved. Produced by Jan Glover, David Izzo, Karen Odato and Lei Wang.
Forming an EBP question
Breaking up your question into these 4 elements (which you can easiliy remember with the acronym PICO) will make your literature search process easier:
Patient, population, &/or problem
Description of the patient, population and/or the target disorder of interest
What are the most important characteristics of the patient?
How would you describe a group of patients similar to yours?
What is the disorder and condition of interest?
Which intervention, prognostic factor, diagnostic tool, or exposure are you considering?
What alternative do you want to compare with the intervention?
Examples: standard of care,
reference standard, Placebo
What outcome you hope to accomplish or measure? [1 & 2]
Hover your cursor over these links for a brief description of each web resource. (Note: These sites are not linked to the GSU Library's collection like the databases listed to the left, so additional steps may be required to determine if articles are available through the library.)
Registry of federally and privately supported clinical trials conducted in the United States and around the world. Provides information about a trial's purpose, who may participate, locations, and phone numbers for more details.