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"Evidence-based practice (EBP) is an approach to health care wherein health professionals use the best evidence possible, i.e., the most appropriate information available, to make clinical decisions
for individual patients. ... It involves complex and conscientious
decision-making based not only on the available evidence but also on patient characteristics, situations, and preferences." 
Evidence-based practice involves 5 steps:
Formulate a searchable question to satisfy the health needs of a specific patient
Search the literature efficiently
Read and critically evaluate the retrieved information to help make a clinical decision
Carry out the decision
Evaluate the outcomes of the applied evidence in your practice or patient [1 & 2]
There is a range in quality of evidence available in the literature, with systematic reviews being the very highest quality:
Indexes 3,000 journals from the fields of nursing and 17 allied health fields. Also indexes health carebooks, selected conference proceedings, standards of practice, book chapters, and Evidence-Based Care Sheets. Here is an excellent guide from UAB to help you find evidence-based practice articles in CINAHL.
Click Advanced Search and see Evidence-Based Practice check box on bottom under Limit your results.
A service of the U.S. National Library of Medicine that indexes MEDLINE citations and other life science journals for biomedical articles.
See Clinical Queries link on left sidebar and Find Systematic Reviews section.
Can also use options under Limits tab to limit a normal PubMed search to certain Type of Article, such as Clinical Trial, Meta-Analysis, Practice Guidelines, Randomized Controlled Trial, Review, Guideline, etc.
For more on searching PubMed, click the Articles tab at top and see the PubMed tutorials in the bottom left of that page.
Unique source of reliable and up-to-date information on the effects of interventions in health care. Designed to provide information and evidence to support decisions taken in health care and to inform those receiving care.
Search box in top right.
Results broken out into 7 categories. Most valuable ones are Cochrane Reviews, Other Reviews, and Clinical Trials.
Sources used to create this guide
 McKibbon KA. Evidence-based practice. Bull Med Libr Assoc. 1998 Jul;86(3):396-401.
 Evidence-Based Practice in the Health Sciences: Evidence-Based Practice in Applied Health Tutorial
Hover your cursor over these links for a brief description of each web resource. (Note: These sites are not linked to the GSU Library's collection like the databases listed to the left, so additional steps may be required to determine if articles are available through the library.)
Registry of federally and privately supported clinical trials conducted in the United States and around the world. Provides information about a trial's purpose, who may participate, locations, and phone numbers for more details.